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Ryan Farley's avatar

Chris you may find the links below interesting. The studies suggest testosterone therapy is associated with potential increased risk for blood clotting. The nejm.org study is from the New England Journal of Medicine and is from trial study released this year.

https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2754091

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204507/

https://www.nejm.org/doi/full/10.1056/NEJMoa2215025

It looks like a small risk but maybe worth taking into consideration if you have genetics that also make you more susceptible.

Take care,

SIncerely,

Ryan

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Chris DeMuth Jr's avatar

Thanks! Much appreciated. Been reading a lot of while papers over this past month and will add these to my pile. One issue I've been confronting is how many associative studies there are that publish without really clear causation (i.e. not really doing the work of studying cross tabs).

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Roo's avatar

Chris is 800mg/day a typo? From the little I know about TRT it sounds like a very high dose

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Chris DeMuth Jr's avatar

Not a typo but possible that I'm not describing this correctly. 4x 200 mg tablets of oral testosterone 1x / day.

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mendo's avatar

That is equivalent to approximately how much of injectable Testosterone enanthate?

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Chris DeMuth Jr's avatar

~146mg/week injected TE.

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Chris DeMuth Jr's avatar

Good question; I don't know but will try to find out.

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Roo's avatar

Ah it's oral! That makes sense. I had assumed injected. Thank you for clarifying

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Chris DeMuth Jr's avatar

I hate injections (although currently injecting myself 2x/day with blood thinners).

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